331 Choppin Hall
Baton Rouge, LA
- IUPAC Fellow
- National Institutes of HealthNanoscale Laser Ablation Capture Mass Spectrometry for Single Cell Proteomics
Single cell analysis is necessary because the ensemble average of cell mixtures obscures important information about human health therefore it is necessary to develop new single cell analysis techniques. Mass spectrometry is one of the most important analysis tools but technological barriers prevent sampling and imaging at the single cell level if large biomolecules such as peptides and proteins are the target analyte. The goal of this research is to develop nanometer scale sampling for mass spectrometry using near-field optics and laser ablation.
Amount: $350844National Institutes of HealthSingle Cell chemical Imaging via nanoscale IR ablation Mass Spectromety
The goal of this Phase I small business technology transfer project is to develop a commercial instrument for nanoscale mass spectrometry imaging based on atomic force microscoy tip enhanced infrared laser ablation. This project involves a collaboration between LSU and Anasys Instruments, Inc.
Amount: $176128National Science FoundationInfrared Laser Ambient Mass Spectrometry
The proposed research is aimed at developing a direct ambient ionization mass spectrometry technique based on infrared (IR) laser desorption combined with electrospray ionization. This work will lead to new instrumentation and techniques for remote sampling and imaging. An infrared laser is used to desorb sample materials under ambient conditions followed by ionization of the material by interaction with an electrospray source. The goals of the research are to 1) understand and control IR laser desorption and ablation, 2) develop IR laser ablation sample transfer mass spectrometry, 3) apply IR laser ablation sample transfer to remote sampling and chemical imaging, 4) develop hands-on mass spectrometry for K-12 teaching.
- LSU Chemistry Professor Secures NIH Grant for Single Cell Analysis Research
LSU Department of Research Communications (2012-10-26)http://sites01.lsu.edu/wp/lsuresearch/20...
T. Musapelo, K. K. Murray (2014) Particle Formation by Infrared Laser Ablation of MALDI Matrix Compounds In: Journal of Mass Spectrometryhttp://dx.doi.org/10.1002/jms.3378
S. –G. Park, K. K. Murray (2014) Ambient Laser Ablation Sampling for Capillary Electrophoresis Mass Spectrometry In: Rapid Communications in Mass Spectrometryhttp://dx.doi.org/10.1002/rcm.6618
T. Musapelo, K. K. Murray (2013) Particle Production in Reflection and Transmission Mode Laser Ablation: Implications for Laserspray Ionization In: Journal of the American Society for Mass Spectrometryhttp://dx.doi.org/10.1007/s13361-013-063...
T. Musapelo, K. K. Murray (2013) Size distributions of ambient shock-generated particles: implications for inlet ionization In: Rapid Communications in Mass Spectrometryhttp://dx.doi.org/10.1002/rcm.6568
B. P. Regmi, N. C. Speller, M. J. Anderson, J. O. Brutus, Y. Merid, S. Das, B. El-Zahab, D. J. Hayes, K. K. Murray, I. M. Warner (2014) Development and analysis of ionic liquid-based QCM sensor for discrimination and molecular weight estimation of organic vapors In: Journal of Materials Chemistry Chttp://dx.doi.org/ 10.1039/C3TC32528H
K. K. Murray, R. K. Boyd, M. N. Eberlin, G. J. Langley, L. Li, Y. Naito (2013) Definitions of terms relating to mass spectrometry (IUPAC Recommendations 2013)” In: Pure and Applied Chemistryhttp://dx.doi.org/10.1351/PAC-REC-06-04-...